Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
| ▸ | FNTB | P49356 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7933150 | 0.84 | NISCH (0.34) | NISCHCHRNB4CHRNA3ACHEPARP10 | |
| Hydrochloric Acid SCHEMBL7936168 | 0.82 | NISCH (0.39) | NISCH | |
| Hydrochloric Acid SCHEMBL7926579 | 0.79 | NISCH (0.35) | NISCHFYNCLK4DYRK1BCHRNB4 | |
| Hydrochloric Acid SCHEMBL7926787 | 0.73 | NISCH (0.35) | NISCHFYNCLK4DYRK1BCHRNB4 | |
| Hydrochloric Acid SCHEMBL27520471 | 0.73 | NISCH (0.39) | NISCHFYNCLK4DYRK1BCHRNB4 | |
| Hydrochloric Acid SCHEMBL27546026 | 0.73 | NISCH (0.39) | NISCHFYNCLK4DYRK1BCHRNB4 | |
| Hydrochloric Acid SCHEMBL27566939 | 0.72 | NISCH (0.38) | NISCHFYNCLK4DYRK1BCHRNB4 | |
| Hydrochloric Acid SCHEMBL27519803 | 0.72 | NISCH (0.38) | NISCHFYNCLK4DYRK1BCHRNB4 | |
| Hydrochloric Acid SCHEMBL7936135 | 0.71 | NISCH (0.33) | NISCHCHRNB4CHRNA3ACHERAB9A | |
| Hydrochloric Acid SCHEMBL27546028 | 0.70 | ACHE (0.37) | NISCHFYNCLK4DYRK1BCHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |