Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7936365 | 0.86 | PTPN1 (0.31) | KDM4EPTPN1ALDH1A1ENPP3ENPP1 | |
| Hydrochloric Acid SCHEMBL7936826 | 0.76 | DHFR (0.34) | KDM4EPTPN1ALPLGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7936169 | 0.76 | IKBKB (0.33) | KDM4EALDH1A1CYP2A6NISCHMAPT | |
| Hydrochloric Acid SCHEMBL8058620 | 0.76 | PTPN1 (0.37) | KDM4EPTPN1ALPLGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL27522615 | 0.74 | PTPN1 (0.36) | KDM4EPTPN1ALPLGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL27520507 | 0.74 | PTPN1 (0.36) | KDM4EPTPN1ALPLGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7933161 | 0.72 | NISCH (0.35) | NISCH | |
| Hydrochloric Acid SCHEMBL7935434 | 0.72 | PTPN1 (0.31) | PTPN1ENPP3ENPP1 | |
| Hydrochloric Acid SCHEMBL7935534 | 0.71 | PTPN1 (0.34) | KDM4EPTPN1ALPLGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL7738902 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |