Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5600335 | 0.87 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL7360292 | 0.82 | CRHR1 (0.70) | CRHR1 | |
| Hydrochloric Acid SCHEMBL8127656 | 0.81 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL5620424 | 0.75 | CRHR1 (0.47) | CRHR1 | |
| Hydrochloric Acid SCHEMBL7953091 | 0.74 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL5611294 | 0.72 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL5600359 | 0.72 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL7935049 | 0.71 | CRHR1 (0.47) | CRHR1TP53 | |
| SCHEMBL7928892 | 0.70 | KDM4E (0.49) | CRHR1TP53KDM4EALDH1A1HPGD | |
| SCHEMBL5844686 | 0.70 | CRHR1 (0.86) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248753-B1 | CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONISTS | PFIZER INC | 2001-06-19 | — | — | US | disclosed |
| EP-0765327-B1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER (US) | 1999-07-21 | — | — | EP | disclosed |
| EP-0765327-A1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995034563-A1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER INC. (US) | 1995-12-21 | — | — | WO | disclosed |