Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.55 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940127 | 0.88 | NPY5R (0.63) | NPY5RMKNK2IGF1RMAP4K4MAPK8 | |
| SCHEMBL7939982 | 0.84 | KDR (0.50) | EGFRNPY5RAURKAJAK2FLT1 | |
| SCHEMBL9352009 | 0.80 | AURKA (0.55) | EGFRNPY5RAURKAPDPK1LCK | |
| SCHEMBL13320047 | 0.78 | IGF1R (0.54) | NPY5RMKNK2IGF1RMAP4K4MAPK8 | |
| SCHEMBL8318514 | 0.78 | EGFR (0.81) | EGFRMKNK2IGF1RMAP4K4MAPK8 | |
| SCHEMBL459413 | 0.72 | IGF1R (0.51) | NPY5RMKNK2IGF1RMAP4K4MAPK8 | |
| SCHEMBL7940120 | 0.72 | BCL6 (0.54) | EGFRIGF1RBCL6KDM4EALDH1A1 | |
| SCHEMBL7937566 | 0.72 | MAPT (0.54) | EGFRAURKAABL1LRRK2KDM4E | |
| SCHEMBL824411 | 0.72 | BCL6 (0.74) | MKNK2IGF1RMAP4K4MAPK8RPS6KA3 | |
| SCHEMBL8316202 | 0.71 | EGFR (0.55) | EGFRMKNK2MAP4K4MAPK8RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232312-B1 | ADMINISTERING A COMBINATION OF INDENE AND PYRIMIDO(5,4-D)PYRIMIDINE DERIVATIVES TO TREAT PREPANCREATIC CANCER | CELL PATHWAYS, INC. | 2001-05-15 | — | — | US | disclosed |