Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.74 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 5/20 | 0.32 |
| ▸ | MMP3 | P08254 | 4/20 | 0.32 |
| ▸ | MMP7 | P09237 | 3/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 4/20 | 0.32 |
| ▸ | MMP8 | P22894 | 3/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946003 | 0.93 | ADAM17 (0.85) | ADAM17CTSCMMP2MMP3MMP7 | |
| SCHEMBL6946135 | 0.93 | ADAM17 (0.85) | ADAM17CTSCMMP2MMP3MMP7 | |
| SCHEMBL6942162 | 0.86 | ADAM17 (0.85) | ADAM17CTSCPSMB5MMP2MMP3 | |
| SCHEMBL3500092 | 0.85 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6813847 | 0.85 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL4481744 | 0.85 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6813844 | 0.85 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL13274076 | 0.85 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6946832 | 0.82 | ADAM17 (0.85) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6943001 | 0.82 | ADAM17 (0.82) | ADAM17MMP2MMP3MMP7MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |