SCHEMBL7937894

SCHEMBL7937894

CCCCNCCCCC1CCCCC1

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.65
SIGMAR1 Q99720 4/20 0.60
TSHR P16473 2/20 0.46
ALDH1A1 P00352 1/20 0.46
TLR7 Q9NYK1 1/20 0.43
BCHE P06276 1/20 0.42
NAAA Q02083 1/20 0.40
GNAI3 P08754 1/20 0.40
GNAO1 P09471 1/20 0.40
GNAI1 P63096 1/20 0.40
CHRNB2 P17787 1/20 0.39
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA4 P43681 1/20 0.39
GRIN1 Q05586 1/20 0.39
GRIN2A Q12879 1/20 0.39
GRM1 Q13255 1/20 0.39
EPHX1 P07099 3/20 0.39
SAT1 P21673 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9207589 0.96 SIGMAR1 (0.60) CYP1A2SIGMAR1TSHRALDH1A1TLR7
SCHEMBL22651943 0.94 SIGMAR1 (0.63) CYP1A2SIGMAR1TSHRALDH1A1NAAA
SCHEMBL5511122 0.94 CYP1A2 (0.68) CYP1A2SIGMAR1TSHRALDH1A1TLR7
SCHEMBL24270878 0.92 CYP1A2 (0.64) CYP1A2SIGMAR1TSHRALDH1A1TLR7
SCHEMBL31560045 0.90 SIGMAR1 (0.58) CYP1A2SIGMAR1TSHRALDH1A1TLR7
SCHEMBL9208675 0.90 CYP1A2 (0.63) CYP1A2SIGMAR1TSHRALDH1A1NAAA
SCHEMBL9213826 0.90 SIGMAR1 (0.63) CYP1A2SIGMAR1TSHRALDH1A1TLR7
SCHEMBL629782 0.90 CYP1A2 (0.61) CYP1A2SIGMAR1TSHRALDH1A1TLR7
SCHEMBL12288486 0.90 CYP1A2 (0.61) CYP1A2SIGMAR1TSHRALDH1A1TLR7
SCHEMBL6625337 0.88 CYP1A2 (0.59) CYP1A2SIGMAR1TSHRALDH1A1BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248919-B1 E.G., (2S)-2-(((5-((BUTYL(2-CYCLOHEXYLETHYL)AMINO)METHYL) -2'-METHYL(1,1'-BIPHENYL)-2-YL)CARBONYL)AMINO)-4-(METHYLSULFAN YL)BUTANOIC ACID, OR A PHARMACEUTICALLY ACCEPTABLE SALT OR PRODRUG THEREOF. ABBOTT LABORATORIES 2001-06-19 US claimed