Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 8/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943249 | 0.90 | ADAM17 (0.53) | ADAM17APP | |
| SCHEMBL6945556 | 0.90 | ADAM17 (0.58) | ADAM17MMP1MMP9MMP14MMP2 | |
| SCHEMBL6946725 | 0.90 | ADAM17 (0.56) | ADAM17MMP9MMP2APP | |
| SCHEMBL6942461 | 0.90 | ADAM17 (0.56) | ADAM17MMP9MMP2APP | |
| SCHEMBL6944384 | 0.90 | ADAM17 (0.51) | ADAM17MMP1MMP3MMP9MMP14 | |
| SCHEMBL6943880 | 0.90 | ADAM17 (0.55) | ADAM17MMP9MMP2APP | |
| SCHEMBL6945793 | 0.90 | ADAM17 (0.55) | ADAM17MMP1MMP3MMP9MMP2 | |
| SCHEMBL6944949 | 0.89 | ADAM17 (0.52) | ADAM17MMP1MMP3MMP9MMP2 | |
| SCHEMBL6942429 | 0.89 | ADAM17 (0.55) | ADAM17MMP1MMP3MMP9MMP14 | |
| SCHEMBL6942509 | 0.89 | ADAM17 (0.55) | ADAM17MMP1MMP9MMP14MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |