Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 5/20 | 0.34 |
| ▸ | MMP3 | P08254 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | MMP13 | P45452 | 4/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 3/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 3/20 | 0.32 |
| ▸ | REN | P00797 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939910 | 0.91 | ADAM17 (0.57) | ADAM17MMP2MMP9APPMEN1 | |
| SCHEMBL6939914 | 0.91 | ADAM17 (0.57) | ADAM17MMP2MMP9APPMEN1 | |
| SCHEMBL7938339 | 0.90 | ADAM17 (0.52) | ADAM17MMP1MMP3MMP2MMP13 | |
| SCHEMBL6943674 | 0.88 | ADAM17 (0.55) | ADAM17MMP3MMP2MEN1KMT2A | |
| SCHEMBL6947109 | 0.88 | ADAM17 (0.57) | ADAM17MMP2MMP9APPMEN1 | |
| SCHEMBL6943561 | 0.88 | ADAM17 (0.67) | ADAM17MMP2MMP9APPMEN1 | |
| SCHEMBL6946725 | 0.87 | ADAM17 (0.56) | ADAM17MMP2MMP9APPTGFBR1 | |
| SCHEMBL6945556 | 0.87 | ADAM17 (0.58) | ADAM17MMP1MMP2MMP13MMP9 | |
| SCHEMBL6943362 | 0.87 | ADAM17 (0.56) | ADAM17MMP2MMP9APPGAA | |
| SCHEMBL6942461 | 0.87 | ADAM17 (0.56) | ADAM17MMP2MMP9APPTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |