Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KLK7 | P49862 | 2/20 | 0.50 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394135 | 0.82 | FOLH1 (0.56) | ABCB1HTTFOLH1 | |
| SCHEMBL14719975 | 0.82 | MAPT (0.57) | ABCB1MAPTKLK7KLK5HTT | |
| SCHEMBL14719974 | 0.82 | MAPT (0.57) | ABCB1MAPTKLK7KLK5HTT | |
| SCHEMBL8955505 | 0.81 | KLK7 (0.64) | ABCB1ITGB3ITGA2BMAPTKLK7 | |
| SCHEMBL14729274 | 0.79 | ABCB1 (0.61) | ABCB1ITGB3ITGA2BMAPTKLK7 | |
| SCHEMBL31114614 | 0.79 | ABCB1 (0.61) | ABCB1ITGB3ITGA2BMAPTKLK7 | |
| SCHEMBL14719981 | 0.79 | MAPT (0.61) | ABCB1ITGB3ITGA2BMAPTKLK7 | |
| SCHEMBL14719934 | 0.79 | MAPT (0.61) | ABCB1ITGB3ITGA2BMAPTKLK7 | |
| SCHEMBL12508122 | 0.79 | MAPT (0.61) | ABCB1ITGB3ITGA2BMAPTKLK7 | |
| SCHEMBL14719982 | 0.79 | MAPT (0.61) | ABCB1ITGB3ITGA2BMAPTKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |