Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 11/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655317 | 0.94 | ENPP2 (0.51) | PI4KBENPP2MAPTMAPK1HTT | |
| SCHEMBL652425 | 0.92 | PI4KB (0.55) | PI4KBENPP2KCNH2MAPTMAPK1 | |
| SCHEMBL655387 | 0.87 | PI4KB (0.53) | PI4KBENPP2KCNH2MAPTMAPK1 | |
| SCHEMBL652412 | 0.85 | PI4KB (0.65) | PI4KBENPP2KCNH2MAPTMAPK1 | |
| SCHEMBL655575 | 0.83 | PI4KB (0.56) | PI4KBENPP2KCNH2MAPTMAPK1 | |
| SCHEMBL655035 | 0.83 | CNR1 (0.51) | PI4KBKCNH2MAPTMAPK1KMT2A | |
| SCHEMBL653995 | 0.83 | PI4KB (0.52) | PI4KBENPP2KCNH2MAPTHTT | |
| SCHEMBL655043 | 0.81 | PI4KB (0.53) | PI4KBKCNH2MAPTMAPK1HTT | |
| SCHEMBL655537 | 0.81 | PI4KB (0.68) | PI4KBENPP2KCNH2MAPTMAPK1 | |
| SCHEMBL794391 | 0.81 | PI4KB (0.52) | PI4KBENPP2KCNH2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |