Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL28515230 | 1.00 | PTPN1 (0.42) | PTPN1TP53CYP2D6LMNASPHK1 | |
| SCHEMBL1890335 | 0.92 | CYP2D6 (0.47) | PTPN1TP53CYP2D6LMNASPHK1 | |
| SCHEMBL142856 | 0.92 | CYP2D6 (0.47) | PTPN1TP53CYP2D6LMNASPHK1 | |
| SCHEMBL28434701 | 0.92 | CYP2D6 (0.47) | PTPN1TP53CYP2D6LMNASPHK1 | |
| SCHEMBL139954 | 0.92 | CYP2D6 (0.47) | PTPN1TP53CYP2D6LMNASPHK1 | |
| SCHEMBL8636200 | 0.92 | CYP2D6 (0.47) | PTPN1TP53CYP2D6LMNASPHK1 | |
| SCHEMBL5963213 | 0.92 | CYP2D6 (0.47) | PTPN1TP53CYP2D6LMNASPHK1 | |
| SCHEMBL2385585 | 0.92 | CYP2D6 (0.47) | PTPN1TP53CYP2D6LMNASPHK1 | |
| SCHEMBL9623258 | 0.92 | CYP2D6 (0.47) | PTPN1TP53CYP2D6LMNASPHK1 | |
| SCHEMBL29064944 | 0.92 | CYP2D6 (0.47) | PTPN1TP53CYP2D6LMNASPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135138-A2 | USE OF 17-KETOSTEROIDS FOR THE TREATMENT OF MALARIA AND TRYPANOSOMIASIS | Hollis-Eden Pharmaceuticals Inc. (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000032201-A2 | USE OF 17-KETOSTEROIDS FOR THE TREATMENT OF MALARIA AND TRYPANOSOMIASIS | HOLLIS-EDEN PHARMACEUTICALS, INC. (US) | 2000-06-08 | — | — | WO | disclosed |
| WO-2000032176-A2 | USE OF 17-KETOSTEROIDS FOR THE TREATMENT OF TOXOPLASMOSIS AND CRYPTOSPORIDOSIS | HOLLIS-EDEN PHARMACEUTICALS, INC. (US) | 2000-06-08 | — | — | WO | disclosed |