Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CDC7 | O00311 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | FLT4 | P35916 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | STK3 | Q13188 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940046 | 0.79 | ADORA2A (0.48) | ADORA2ACDK2CDK1CCNB1CCNE1 | |
| SCHEMBL7930934 | 0.77 | CDK1 (0.43) | ADORA2ALIMK1CDK2CDC7CDK1 | |
| SCHEMBL7942505 | 0.77 | LMNA (0.45) | ADORA2AMAP4K4PI4KAPI4K2BPI4K2A | |
| SCHEMBL16094493 | 0.69 | HSP90B1 (0.33) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL5989622 | 0.69 | ADORA2A (0.41) | ADORA2ACDK2CDK1DYRK1ACSNK1A1 | |
| SCHEMBL6416647 | 0.68 | EGFR (0.44) | MAP4K4PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL4815326 | 0.67 | ADORA2A (0.41) | ADORA2ACDK2CDK1CCNB1CCNE1 | |
| SCHEMBL5386086 | 0.67 | ADORA2A (0.55) | ADORA2AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL22715826 | 0.66 | ADORA2A (0.41) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL22715627 | 0.66 | ADORA2A (0.37) | ADORA2AMAP4K4PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968329-A1 | NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME | Galleon Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151462-A1 | NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME | GALLEON PHARMACEUTICALS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| US-6232312-B1 | ADMINISTERING A COMBINATION OF INDENE AND PYRIMIDO(5,4-D)PYRIMIDINE DERIVATIVES TO TREAT PREPANCREATIC CANCER | CELL PATHWAYS, INC. | 2001-05-15 | — | — | US | disclosed |