Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748357 | 0.80 | CCR1 (0.48) | NR4A2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL627005 | 0.80 | S1PR4 (0.46) | NR4A2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6750524 | 0.73 | KDM4E (0.67) | CYSLTR2CYSLTR1KDM4EMEN1KMT2A | |
| SCHEMBL13513030 | 0.73 | CYSLTR1 (0.59) | CYSLTR2CYSLTR1KDM4EMEN1KMT2A | |
| SCHEMBL4476236 | 0.72 | NPC1 (0.57) | CYSLTR2CYSLTR1KDM4EMEN1KMT2A | |
| SCHEMBL5833376 | 0.72 | NR4A2 (0.50) | NR4A2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL30506415 | 0.72 | NR4A2 (0.54) | NR4A2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2133059 | 0.72 | NR4A2 (0.54) | NR4A2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL10421430 | 0.71 | KDM4E (0.65) | CYSLTR2CYSLTR1KDM4EMEN1KMT2A | |
| SCHEMBL6969863 | 0.71 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102690229-A | Brand new synthesis of Montelukast Sodium and its preparation intermediates | SHANGHAI XIANGHUI MEDICAL TECHNOLOGY CO LTD | 2012-09-26 | — | — | CN | claimed |
| CN-101808997-A | Process and intermediates for the production of tertiary alcohols as intermediates in the synthesis of montelukast | LONZA AG | 2010-08-18 | — | — | CN | claimed |
| CN-101356158-B | intermediates for the preparation of montelukast and related compounds | SYNTHON B.V. (NL) | 2011-12-14 | — | — | CN | disclosed |
| CN-101356157-B | Process for making montelukast and intermediates therefor | SYNTHON BV | 2011-07-06 | — | — | CN | disclosed |
| CN-101889081-A | Ketoreductase polypeptides and uses thereof | CODEXIS INC | 2010-11-17 | — | — | CN | disclosed |
| CN-101365683-A | Process for making montelukast and intermediates therefor | SYNTHON BV (NL) | 2009-02-11 | — | — | CN | disclosed |
| CN-101356157-A | Process for making montelukast and intermediates therefor | SYNTHON BV (NL) | 2009-01-28 | — | — | CN | disclosed |
| CN-101356158-A | Novel intermediates for the preparation of montelukast and related compounds | SYNTHON BV (NL) | 2009-01-28 | — | — | CN | disclosed |
| EP-1123091-A1 | COMBINATION PRODUCT COMPRISING AN E-TYPE PROSTAGLANDIN LIGAND AND A COX-2 SELECTIVE INHIBITOR AND METHODS OF USE | Merck Frosst Canada & Co. (CA) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024393-A1 | COMBINATION PRODUCT COMPRISING AN E-TYPE PROSTAGLANDIN LIGAND AND A COX-2 SELECTIVE INHIBITOR AND METHODS OF USE | MERCK FROSST CANADA & CO. (CA) | 2000-05-04 | — | — | WO | disclosed |
| CN-1040108-C | Pharmaceutical compounds | LILLY INDUSTRIES LTD (GB) | 1998-10-07 | — | — | CN | disclosed |