Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | ECE2 | P0DPD6 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28443608 | 0.81 | RAB9A (0.80) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL524926 | 0.81 | RAB9A (0.61) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL8414907 | 0.77 | NPC1 (0.57) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL3810519 | 0.77 | RAB9A (0.57) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL4060701 | 0.77 | NPC1 (0.57) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL267838 | 0.77 | RAB9A (0.57) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL4068608 | 0.77 | NPC1 (0.57) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL108424 | 0.77 | RAB9A (0.57) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL1163115 | 0.77 | RAB9A (0.57) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL1163637 | 0.77 | NPC1 (0.62) | NPC1RAB9ALMNAKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351940-B1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF PROTOZOAN AND RETROVIRUS CO-INFECTIONS | INST RECH DEVELOPPEMENT IRD (FR) | 2007-07-25 | — | — | EP | claimed |
| CN-1144786-C | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors | 谷 | 2004-04-07 | — | — | CN | claimed |
| EP-1351940-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF PROTOZOAN AND RETROVIRUS CO-INFECTIONS | Institut de Recherche pour le Développement ( IRD) (FR) | 2003-10-15 | — | — | EP | claimed |
| WO-2002057238-A1 | SUBSTITUTED QUINOLINES FOR THE TREATMENT OF PROTOZOAN AND RETROVIRUS CO-INFECTIONS | INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) (FR) | 2002-07-25 | — | — | WO | claimed |
| CN-1320118-A | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors | AMERICAN CYANAMID CO (US) | 2001-10-31 | — | — | CN | claimed |
| US-4322487-A | Composite electrically photosensitive particles for electrophoretic migration imaging process | EASTMAN KODAK COMPANY (US) | 1982-03-30 | — | — | US | claimed |
| US-7576094-B2 | Spiro derivatives as lipoxygenase inhibitors | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | disclosed |
| EP-1856079-A4 | SPIRO-HETEROCYCLIC CHROMANS, THIOCHROMANS AND DIHYDROQUINOLINES | GALILEO PHARMACEUTICALS INC (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20080207588-A1 | Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines | CHU DANIEL T W | 2008-08-28 | — | — | US | disclosed |
| CN-101163687-A | Spiro-heterocyclic chromans, thiochromans and dihydroquinolines | GALILEO PHARMACEUTICALS INC (US) | 2008-04-16 | — | — | CN | disclosed |
| CN-101128423-A | Novel lipoxygenase inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |
| CN-101115734-A | Spiro derivatives as lipoxygenase inhibitors | LILLY CO ELI (US) | 2008-01-30 | — | — | CN | disclosed |
| EP-1856040-A2 | NOVEL LIPOXYGENASE INHIBITORS | Eli Lilly and Company (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-1996002506-A1 | QUINOLINE DERIVATIVES AS LEUKOTRIENE ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1996-02-01 | — | — | WO | disclosed |
| US-5457225-A | Process for preparation of 5-hydroxy-3-ketoester derivative and optically active substance thereof | UBE INDUSTRIES LTD. (JP) | 1995-10-10 | — | — | US | disclosed |
| EP-0670831-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995009159-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-04-06 | — | — | WO | disclosed |
| EP-0641762-A1 | Process for preparation of 5-hydroxy-3-ketoester derivative and optically active substance thereof | UBE INDUSTRIES, LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |
| US-4322487-A | Composite electrically photosensitive particles for electrophoretic migration imaging process | EASTMAN KODAK COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| EP-0024169-A2 | Electrically photosensitive particles for electrophoretic migration imaging processes, dispersions of these particles, and processes using such dispersions | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1981-02-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207588-A1 | Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines | CBR3, CBR1, DHRS9 | NPC1 2133/4885RAB9A 611/4885LMNA 4323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.