Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 11/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cetrimonium SCHEMBL10869268 | 0.97 | DNM1 (0.46) | DNM1HSP90AA1RAD52APAF1HTT | |
| Cetrimonium SCHEMBL10647447 | 0.91 | DNM1 (0.48) | DNM1HSP90AA1RAD52APAF1HTT | |
| Tetrabuthylammonium SCHEMBL9495552 | 0.83 | SLC22A1 (0.40) | MEN1KMT2A | |
| Tetrabuthylammonium SCHEMBL2184844 | 0.83 | SLC22A1 (0.40) | MEN1KMT2A | |
| Tetrabuthylammonium SCHEMBL7700891 | 0.81 | SLC22A1 (0.38) | MEN1KMT2A | |
| SCHEMBL1701168 | 0.81 | SLC22A1 (0.38) | MEN1KMT2A | |
| Tetrapropylammonium SCHEMBL1701184 | 0.80 | THRB (0.41) | — | |
| Trifluoroacetic Acid SCHEMBL15355428 | 0.80 | DNM1 (0.58) | DNM1HSP90AA1RAD52APAF1HTT | |
| Cetrimonium SCHEMBL4809388 | 0.80 | DNM1 (0.58) | DNM1HSP90AA1RAD52APAF1HTT | |
| SCHEMBL21986631 | 0.78 | DNM1 (0.42) | DNM1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6261350-B1 | FIXING | HEWLETT-PACKARD COMPANY | 2001-07-17 | — | — | US | disclosed |