Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.58 |
| ▸ | HTR3B | O95264 | 5/20 | 0.58 |
| ▸ | HTR3A | P46098 | 5/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | SCN1A | P35498 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250517 | 0.93 | KDM4E (0.65) | PDE10AKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL31673005 | 0.93 | KDM4E (0.65) | PDE10AKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL9198147 | 0.92 | HTR3E (0.61) | PDE10AKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL29176330 | 0.91 | HTR3E (0.61) | PDE10AKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL9198080 | 0.91 | HTR3E (0.61) | PDE10AKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL9203821 | 0.88 | KDM4E (0.64) | PDE10AKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL13490841 | 0.86 | KDM4E (0.55) | PDE10AKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL28337139 | 0.84 | KDM4E (0.71) | PDE10AKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL28378761 | 0.82 | KDM4E (0.62) | PDE10AKDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL89106 | 0.82 | HTR3E (0.48) | PDE10AKDM4EHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001095903-A1 | 5-HT3 RECEPTOR ANTAGONISTS FOR TREATMENT OF DISORDERS INVOLVING AIRWAY CONSTRICTION | RESPIRATORIUS AB (SE) | 2001-12-20 | — | — | WO | disclosed |
| EP-0564650-B1 | QUINOLINE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1995-09-20 | — | — | EP | disclosed |
| US-5319085-A | Antiemetic agents; anticarcinogenic agent-induced vomiting; antianxiolytic agents; psychological disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0564650-A1 | QUINOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-10-13 | — | — | EP | disclosed |