Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.46 |
| ▸ | ACLY | P53396 | 2/20 | 0.44 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557174 | 0.91 | PTGES2 (0.45) | HDAC1CXCR1CXCR2PTGES2CCR2 | |
| SCHEMBL7496445 | 0.89 | ACLY (0.52) | CXCR1CXCR2PTGES2CCR2GPR27 | |
| SCHEMBL7490402 | 0.86 | GPR27 (0.51) | CXCR1CXCR2PTGES2CCR2GPR27 | |
| SCHEMBL7487824 | 0.86 | TBXA2R (0.50) | CXCR1CXCR2PTGES2CCR2ACLY | |
| SCHEMBL3709166 | 0.86 | CXCR2 (0.63) | CXCR1CXCR2PTGES2CCR2GPR27 | |
| SCHEMBL7493701 | 0.85 | STAT3 (0.51) | CXCR1CXCR2PTGES2CCR2GPR27 | |
| SCHEMBL7491182 | 0.84 | GPR27 (0.51) | CXCR1CXCR2PTGES2CCR2GPR27 | |
| SCHEMBL7555940 | 0.84 | SLC22A12 (0.52) | CXCR1CXCR2PTGES2CCR2GPR27 | |
| SCHEMBL7487912 | 0.84 | CXCR1 (0.45) | CXCR1CXCR2PTGES2CCR2GPR27 | |
| SCHEMBL7487915 | 0.84 | CXCR1 (0.45) | CXCR1CXCR2PTGES2CCR2GPR27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262113-B1 | HYDROXY- OR MERCAPTO-PHENYLUREAS | SMITHKLINE BEECHAM CORPORATION | 2001-07-17 | — | — | US | disclosed |