Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7553211 | 0.83 | MAOB (0.43) | MAOBMAOACYP19A1ADRB2MRGPRX4 | |
| SCHEMBL18217414 | 0.81 | MAOB (0.47) | MAOBMAOACYP19A1ADRB2MRGPRX4 | |
| SCHEMBL11210106 | 0.81 | MAOB (0.47) | MAOBMAOACYP19A1ADRB2MRGPRX4 | |
| SCHEMBL7600364 | 0.75 | TACR1 (0.46) | MAOBMAOACYP19A1TAAR1SLC6A2 | |
| SCHEMBL14886811 | 0.72 | MAOB (0.42) | MAOBMAOACYP19A1ADRB2MRGPRX4 | |
| SCHEMBL11059954 | 0.71 | PNMT (0.62) | MAOBMAOACYP19A1ADRB2TAAR1 | |
| SCHEMBL30601044 | 0.71 | MAOB (0.52) | MAOBMAOACYP19A1MRGPRX4ACHE | |
| SCHEMBL633486 | 0.71 | MAOB (0.52) | MAOBMAOACYP19A1MRGPRX4ACHE | |
| SCHEMBL951869 | 0.71 | PNMT (0.62) | MAOBMAOACYP19A1ADRB2TAAR1 | |
| SCHEMBL11056699 | 0.71 | PNMT (0.62) | MAOBMAOACYP19A1ADRB2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262124-B1 | FOR ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS, FOR EXAMPLE, AS AGONISTS OF SPECIFIC NICOTINIC RECEPTOR SUBTYPES; FOR THERAPY OF DYSFUNCTION OF THE CENTRAL AND AUTONOMIC NERVOUS SYSTEMS | TARGACEPT, INC., A CORPORATION OF DELAWARE | 2001-07-17 | — | — | US | disclosed |