SCHEMBL7940145

SCHEMBL7940145

O=C1Cc2ccccc2C1=C1Cc2ccccc2C1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 2/20 0.57
BCHE P06276 1/20 0.57
MAOA P21397 3/20 0.50
CYP1A2 P05177 3/20 0.44
HRH1 P35367 2/20 0.44
HRH4 Q9H3N8 2/20 0.44
ALDH1A1 P00352 6/20 0.44
HPGD P15428 3/20 0.44
KDM4E B2RXH2 2/20 0.44
CYP2C19 P33261 2/20 0.43
LMNA P02545 1/20 0.43
CHRM2 P08172 1/20 0.43
CHRM4 P08173 1/20 0.43
CYP3A4 P08684 1/20 0.43
CHRM5 P08912 1/20 0.43
ADRA2A P08913 1/20 0.43
CYP2D6 P10635 1/20 0.43
CHRM1 P11229 1/20 0.43
TSHR P16473 1/20 0.43
ADRA2B P18089 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18032688 0.87 CES1 (0.67) CES1BCHEMAOACYP1A2HRH1
SCHEMBL7934052 0.84 CES1 (0.53) CES1BCHEMAOACYP1A2HRH1
SCHEMBL21801602 0.82 MAOA (0.50) CES1BCHEMAOACYP1A2HRH1
SCHEMBL3638469 0.78 CES1 (0.67) CES1BCHEMAOACYP1A2ALDH1A1
SCHEMBL31392106 0.78 CES1 (0.67) CES1BCHEMAOACYP1A2ALDH1A1
SCHEMBL31070117 0.77
SCHEMBL569873 0.77
SCHEMBL8035811 0.77 CES1 (0.73) CES1BCHEMAOACYP1A2ALDH1A1
SCHEMBL14441607 0.74 CYP1A2 (0.67) CES1BCHEMAOACYP1A2ALDH1A1
SCHEMBL31392781 0.74 CYP1A2 (0.67) CES1BCHEMAOACYP1A2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6300376-B1 FOR THERAPY TO ACHIEVE SMOOTH MUSCLE RELAXING ACTIVITY AND/OR MAST CELL STABILIZING ACTIVITY AND/OR ANTI-INFLAMMATORY ACTIVITY VENANTIUS LIMITED (IR) 2001-10-09 US disclosed
WO-1997020802-A1 INDANE DIMER COMPOUNDS AND THEIR PHARMACEUTICAL USE VENANTIUS LIMITED (IE) 1997-06-12 WO disclosed