Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.53 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.68 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.56 |
| ▸ | RAD52 | P43351 | 2/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.56 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.56 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31347471 | 0.98 | HTT (0.71) | HTTDNM1KMT2AHSP90AA1RAD52 | |
| SCHEMBL31347475 | 0.98 | HTT (0.71) | HTTDNM1KMT2AHSP90AA1RAD52 | |
| Bromide SCHEMBL11651371 | 0.95 | DNM1 (0.70) | HTTDNM1KMT2AHSP90AA1RAD52 | |
| Bromide SCHEMBL11440547 | 0.95 | DNM1 (0.70) | HTTDNM1KMT2AHSP90AA1RAD52 | |
| Bromide SCHEMBL11440640 | 0.95 | DNM1 (0.70) | HTTDNM1KMT2AHSP90AA1RAD52 | |
| SCHEMBL13701161 | 0.93 | HTT (0.65) | HTTDNM1KMT2AHSP90AA1RAD52 | |
| SCHEMBL13701162 | 0.93 | HTT (0.65) | HTTDNM1KMT2AHSP90AA1RAD52 | |
| Iodide SCHEMBL10492597 | 0.91 | HTT (0.62) | HTTDNM1KMT2AHSP90AA1RAD52 | |
| Bromide SCHEMBL10492636 | 0.91 | DNM1 (0.64) | HTTDNM1KMT2AHSP90AA1RAD52 | |
| Fluoride Ion SCHEMBL10492624 | 0.91 | HTT (0.62) | HTTDNM1KMT2AHSP90AA1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200369-B1 | WATER, COLORANT AND AMINE CONTAINING ADDITIVE | XEROX CORPORATION | 2001-03-13 | — | — | US | disclosed |