Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.72 |
| ▸ | POLH | Q9Y253 | 8/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.72 |
| ▸ | POLB | P06746 | 5/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | GAA | P10253 | 4/20 | 0.72 |
| ▸ | RECQL | P46063 | 4/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | APEX1 | P27695 | 3/20 | 0.72 |
| ▸ | MMP1 | P03956 | 2/20 | 0.72 |
| ▸ | BLM | P54132 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | SRC | P12931 | 5/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31236662 | 0.88 | POLH (0.76) | EPHX2POLHKDM4EPOLBMEN1 | |
| SCHEMBL4175201 | 0.88 | POLH (0.76) | EPHX2POLHKDM4EPOLBMEN1 | |
| SCHEMBL14786208 | 0.86 | POLH (0.81) | EPHX2POLHKDM4EPOLBMEN1 | |
| SCHEMBL23442030 | 0.86 | EPHX2 (0.88) | EPHX2POLHKDM4EPOLBMEN1 | |
| SCHEMBL23442126 | 0.86 | EPHX2 (0.88) | EPHX2POLHKDM4EPOLBMEN1 | |
| SCHEMBL28040773 | 0.85 | EPHX2 (0.69) | EPHX2POLHKDM4EPOLBMEN1 | |
| SCHEMBL23441996 | 0.85 | EPHX2 (0.82) | EPHX2POLHKDM4EPOLBMEN1 | |
| SCHEMBL4170634 | 0.85 | POLH (0.74) | EPHX2POLHKDM4EPOLBMEN1 | |
| SCHEMBL15928808 | 0.85 | POLH (0.71) | EPHX2POLHKDM4EPOLBMEN1 | |
| SCHEMBL28297226 | 0.85 | POLH (0.79) | EPHX2POLHKDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258840-B1 | ANTITUMOR AGENTS, ANTIINFLAMMATORY AGENTS, ENZYME INHIBITORS OF KINASES | COBRA THERAPEUTICS LIMITED (GB) | 2001-07-10 | — | — | US | claimed |
| US-6258840-B1 | ANTITUMOR AGENTS, ANTIINFLAMMATORY AGENTS, ENZYME INHIBITORS OF KINASES | COBRA THERAPEUTICS LIMITED (GB) | 2001-07-10 | — | — | US | disclosed |
| EP-0912541-A1 | ANALOGUES OR DERIVATIVES OF QUERCETIN (PRODRUGS) | Cobra Therapeutics Limited (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997049693-A1 | ANALOGUES OR DERIVATIVES OF QUERCETIN (PRODRUGS) | COBRA THERAPEUTICS LIMITED (GB) | 1997-12-31 | — | — | WO | disclosed |