Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.53 |
| ▸ | CTSV | O60911 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7939801 | 0.88 | CHRNB2 (0.44) | PSMB5MEN1KMT2ALMNATDP1 | |
| SCHEMBL7940901 | 0.86 | PSMB5 (0.53) | PSMB5MEN1KMT2ALMNATDP1 | |
| SCHEMBL7778087 | 0.85 | LMNA (0.71) | PSMB5MEN1KMT2ALMNATDP1 | |
| SCHEMBL16452917 | 0.85 | LMNA (0.71) | PSMB5MEN1KMT2ALMNATDP1 | |
| SCHEMBL4889588 | 0.85 | LMNA (0.71) | PSMB5MEN1KMT2ALMNATDP1 | |
| SCHEMBL9716670 | 0.85 | LMNA (0.71) | PSMB5MEN1KMT2ALMNATDP1 | |
| SCHEMBL10665563 | 0.84 | LMNA (0.73) | PSMB5MEN1KMT2ALMNATDP1 | |
| SCHEMBL9234559 | 0.84 | LMNA (0.73) | PSMB5MEN1KMT2ALMNATDP1 | |
| SCHEMBL5612699 | 0.84 | LMNA (0.73) | PSMB5MEN1KMT2ALMNATDP1 | |
| SCHEMBL7939814 | 0.82 | NPC1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242448-B1 | Trisubstituted-oxazole derivatives as serotonin ligands | AMERICAN HOME PRODUCTS CORPORATION | 2001-06-05 | — | — | US | disclosed |
| EP-1053235-A1 | OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-22 | — | — | EP | disclosed |
| US-6057340-A | Oxazole derivatives as serotonin-1A receptor agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1999038864-A1 | OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-05 | — | — | WO | disclosed |