Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1829388 | 1.00 | CYP19A1 (0.38) | CYP19A1ADRA2AMAPTCYP3A4RAB9A | |
| SCHEMBL12607167 | 0.83 | CYP19A1 (0.37) | CYP19A1ADRA2AMAPTCYP3A4RAB9A | |
| SCHEMBL7943981 | 0.82 | BACE1 (0.36) | ALDH1A1PARP1 | |
| SCHEMBL15157957 | 0.78 | CYP19A1 (0.40) | CYP19A1ADRA2AMAPTCYP3A4RAB9A | |
| SCHEMBL15157956 | 0.78 | CYP19A1 (0.40) | CYP19A1ADRA2AMAPTCYP3A4RAB9A | |
| SCHEMBL7942826 | 0.73 | CTDSP1 (0.47) | MAPTCYP3A4RAB9AALDH1A1NPC1 | |
| SCHEMBL1826971 | 0.73 | CTDSP1 (0.47) | MAPTCYP3A4RAB9AALDH1A1NPC1 | |
| SCHEMBL4597742 | 0.70 | CYP19A1 (0.40) | CYP19A1ADRA2APARP1 | |
| SCHEMBL1265527 | 0.70 | CYP19A1 (0.46) | CYP19A1ADRA2AMAPTPARP1 | |
| SCHEMBL1266361 | 0.70 | LMNA (0.40) | CYP19A1ADRA2AMAPTCYP3A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501733-B2 | Spiroaminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-06 | — | — | US | disclosed |
| WO-2010013794-A1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-02-04 | — | — | WO | disclosed |