Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1826971 | 1.00 | CTDSP1 (0.47) | CTDSP1TDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL7914195 | 0.84 | CTDSP1 (0.63) | CTDSP1TDP1MAPTRAB9AALDH1A1 | |
| SCHEMBL29959883 | 0.81 | CTDSP1 (0.38) | CTDSP1TDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL15157957 | 0.80 | CYP19A1 (0.40) | MAPTRAB9AALDH1A1NPC1CYP1A2 | |
| SCHEMBL5480595 | 0.80 | CTDSP1 (0.43) | CTDSP1TDP1MAPTRAB9AALDH1A1 | |
| SCHEMBL29961371 | 0.80 | CTDSP1 (0.43) | CTDSP1TDP1MAPTRAB9AALDH1A1 | |
| SCHEMBL10463565 | 0.80 | CTDSP1 (0.43) | CTDSP1TDP1MAPTRAB9AALDH1A1 | |
| SCHEMBL1346560 | 0.76 | CTDSP1 (0.40) | CTDSP1TDP1MAPTRAB9AALDH1A1 | |
| SCHEMBL10407756 | 0.76 | CTDSP1 (0.40) | CTDSP1TDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL1346558 | 0.76 | CTDSP1 (0.40) | CTDSP1TDP1MAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318416-B1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| US-8501733-B2 | Spiroaminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-06 | — | — | US | disclosed |
| US-20110152253-A1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-06-23 | — | — | US | disclosed |
| WO-2010013794-A1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152253-A1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | BACE1, BACE2, APP | CTDSP1 2352/4885TDP1 598/4885L3MBTL1 4136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.