Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PMM2 | O15305 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949718 | 0.83 | ALDH1A1 (0.48) | KMT2AMEN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL4548125 | 0.73 | MEN1 (0.52) | KMT2AMEN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL9736258 | 0.72 | MAPT (0.50) | KMT2AMEN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL11183526 | 0.71 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL10426398 | 0.71 | MEN1 (0.55) | KMT2AMEN1ALDH1A1MAPTMGLL | |
| SCHEMBL9736266 | 0.71 | ALDH1A1 (0.63) | KMT2AALDH1A1MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL29510718 | 0.71 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL22493009 | 0.71 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3957049 | 0.69 | SMN1; SMN2 (0.50) | KMT2AALDH1A1MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL3435526 | 0.69 | HTT (0.46) | KMT2AALDH1A1MAPTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268496-B1 | GAMMA-AMINOBUTYRIC ACID RECEPTOR LIGANDS | NEUROGEN CORPORATION | 2001-07-31 | — | — | US | disclosed |
| EP-0555391-B1 | CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5744602-A | PSYCHOLOGICAL DISORDERS, ANTICONVULSANTS | NEUROGEN CORPORATION (US) | 1998-04-28 | — | — | US | disclosed |