Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | CRHBP | P24387 | 1/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11780689 | 0.99 | KMT2A (0.61) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL6422578 | 0.91 | KMT2A (0.65) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL4753200 | 0.89 | KMT2A (0.59) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL11776974 | 0.87 | TSHR (0.57) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL11780686 | 0.87 | KMT2A (0.61) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL28066675 | 0.87 | KMT2A (0.57) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL28230924 | 0.85 | KMT2A (0.56) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL18779429 | 0.85 | KMT2A (0.58) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL1978668 | 0.84 | TSHR (0.75) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL1981486 | 0.84 | KMT2A (0.67) | KMT2AALDH1A1MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268496-B1 | GAMMA-AMINOBUTYRIC ACID RECEPTOR LIGANDS | NEUROGEN CORPORATION | 2001-07-31 | — | — | US | disclosed |
| EP-0555391-B1 | CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5744602-A | PSYCHOLOGICAL DISORDERS, ANTICONVULSANTS | NEUROGEN CORPORATION (US) | 1998-04-28 | — | — | US | disclosed |
| CN-1034174-C | Certain imidazoquinoxalines, a new class of GABA brain receptor ligands | NEUROGEN CORP (US) | 1997-03-05 | — | — | CN | disclosed |
| CN-1076930-A | Some imidazo quinoxaline compound; The γ-An Jidingsuan brain receptor ligands that one class is new | NEUROGEN CORP (US) | 1993-10-06 | — | — | CN | disclosed |
| EP-0555391-A1 | CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-08-18 | — | — | EP | disclosed |
| US-5130430-A | Anxiety, sleep disorders or seizures | NEUROGEN CORPORATION (US) | 1992-07-14 | — | — | US | disclosed |
| WO-1992007853-A1 | CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-05-14 | — | — | WO | disclosed |