Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.40 |
| ▸ | CNR1 | P21554 | 4/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12211865 | 1.00 | MAPK8 (0.46) | MAPK8CYP19A1CYP11B1CYP11B2USP30 | |
| SCHEMBL12733177 | 1.00 | MAPK8 (0.46) | MAPK8CYP19A1CYP11B1CYP11B2USP30 | |
| SCHEMBL1606436 | 0.89 | CYP11B2 (0.56) | MAPK8CYP19A1CYP11B1CYP11B2USP30 | |
| SCHEMBL1605733 | 0.89 | CYP11B2 (0.56) | MAPK8CYP19A1CYP11B1CYP11B2USP30 | |
| SCHEMBL1605729 | 0.89 | CYP11B2 (0.56) | MAPK8CYP19A1CYP11B1CYP11B2USP30 | |
| SCHEMBL12212621 | 0.80 | MAPK8 (0.43) | MAPK8CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL12733182 | 0.77 | CYP11B2 (0.45) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7946875 | 0.77 | CYP11B2 (0.45) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL651891 | 0.74 | HTT (0.53) | MAPK8USP30CNR1 | |
| SCHEMBL652820 | 0.74 | HTT (0.53) | MAPK8USP30CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009156462-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-12-30 | — | — | WO | disclosed |