Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12733182 | 1.00 | CYP11B2 (0.45) | CYP11B2CYP11B1CYP19A1KDM1ADDR1 | |
| SCHEMBL1605853 | 0.87 | CYP11B2 (0.62) | CYP11B2CYP11B1CYP19A1KDM1ADDR1 | |
| SCHEMBL1605732 | 0.87 | CYP11B2 (0.62) | CYP11B2CYP11B1CYP19A1KDM1ADDR1 | |
| SCHEMBL1605728 | 0.87 | CYP11B2 (0.62) | CYP11B2CYP11B1CYP19A1KDM1ADDR1 | |
| SCHEMBL12212637 | 0.77 | CYP11B2 (0.49) | CYP11B2CYP11B1CYP19A1MAOA | |
| SCHEMBL12733177 | 0.77 | MAPK8 (0.46) | CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL7941970 | 0.77 | MAPK8 (0.46) | CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL12211865 | 0.77 | MAPK8 (0.46) | CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL12212625 | 0.75 | CYP11B2 (0.42) | CYP11B2CYP11B1CYP19A1MAOAKCNH2 | |
| SCHEMBL12212633 | 0.73 | CYP11B2 (0.41) | CYP11B2CYP11B1CYP19A1KDM1ADDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030334-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-10-04 | — | — | US | disclosed |
| US-20100261698-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-10-14 | — | — | US | disclosed |
| WO-2009156462-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261698-A1 | ORGANIC COMPOUNDS | SLCO2B1, SLCO1B1, SLCO1B3 | CYP11B2 13/4885CYP11B1 14/4885CYP19A1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.