Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12727176 | 0.94 | TGFBR1 (0.51) | MAPK14HCAR1TGFBR1MMP13MEN1 | |
| SCHEMBL1640318 | 0.89 | TGFBR1 (0.58) | MAPK14TGFBR1MMP13GPR119GRIA1 | |
| SCHEMBL1640811 | 0.89 | GPR119 (0.53) | HCAR1GPR119 | |
| SCHEMBL6953086 | 0.88 | MAPK14 (0.64) | MAPK14MEN1KMT2A | |
| SCHEMBL15824383 | 0.88 | MAPK14 (0.50) | MAPK14HCAR1TGFBR1MMP13MEN1 | |
| SCHEMBL15830851 | 0.88 | MAPK14 (0.50) | MAPK14HCAR1TGFBR1MMP13MEN1 | |
| SCHEMBL4913562 | 0.84 | MAPK14 (0.65) | MAPK14HCAR1TGFBR1GPR119GRIA1 | |
| SCHEMBL1640844 | 0.82 | MAPK14 (0.44) | MAPK14TGFBR1 | |
| SCHEMBL1640964 | 0.81 | MAPK14 (0.59) | MAPK14TGFBR1GPR119 | |
| SCHEMBL17083890 | 0.81 | GPR119 (0.53) | HCAR1MEN1KMT2AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255491-B1 | CHEMICAL INTERMEDIATES SUCH AS 1-(SUBSTITUTED), 4-ARYL, 5-(3-N,N-DISUBSTITUTED AMINO-1-PROPENONE) IMIDAZOLE, USEFUL FOR MAKING 5-PYRIMIDINYL IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION | 2001-07-03 | — | — | US | disclosed |
| US-6239279-B1 | THERAPY FOR CYTOKINE SENSITIVE DISEASES | SMITHKLINE BEECHAM CORPORATION | 2001-05-29 | — | — | US | disclosed |
| US-6100399-A | Synthesis for 4-aryl-5-pyrimidine imidazole substituted compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-08 | — | — | US | disclosed |
| US-5917043-A | INTERMEDIATES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-29 | — | — | US | disclosed |