SCHEMBL7942817

SCHEMBL7942817

Brc1c(OCc2ccccc2)sc2cc(OCc3ccccc3)ccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.49
MAOB P27338 10/20 0.49
ALOX5 P09917 1/20 0.47
MAOA P21397 3/20 0.46
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CTSV O60911 1/20 0.43
CTSL P07711 1/20 0.43
LMNA P02545 1/20 0.42
CYP1A2 P05177 1/20 0.42
PTGS1 P23219 1/20 0.42
SLC6A2 P23975 1/20 0.42
CYP2C19 P33261 1/20 0.42
PTGS2 P35354 1/20 0.42
SLC6A3 Q01959 1/20 0.42
HIF1A Q16665 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7942884 0.91 MAOB (0.49) CYP3A4MAOB
SCHEMBL7944431 0.91 MAOB (0.49) CYP3A4MAOBALOX5MAOACA12
SCHEMBL31483501 0.87 MAOB (0.50) CYP3A4MAOBALOX5MAOACA12
SCHEMBL4515585 0.87 MAOB (0.50) CYP3A4MAOBALOX5MAOACA12
SCHEMBL7946159 0.86 PTGS2 (0.42) MAOBMAOALMNACYP1A2PTGS1
SCHEMBL7946154 0.84 LMNA (0.49) CYP3A4MAOBALOX5MAOACA12
SCHEMBL30610949 0.80 MAOB (0.47) CYP3A4MAOBALOX5MAOACA12
SCHEMBL17845120 0.80 MAOB (0.47) CYP3A4MAOBALOX5MAOACA12
SCHEMBL8165605 0.80 MAOB (0.49) MAOBMAOAALDH1A1MAPTRAB9A
SCHEMBL7942882 0.79 CYP1A2 (0.50) CYP3A4MAOBALOX5MAOALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258826-B1 HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS ELI LILLY AND COMPANY 2001-07-10 US claimed
US-6087378-A THE ACTIVE BENZO(B)THIOPHENE COMPOUNDS FOR TREATING OSTEOPOROSIS AND CARDIOVASCULAR DISORDERS, ESPECIALLY HYPERLIPIDEMIA ELI LILLY AND COMPANY (US) 2000-07-11 US claimed
US-6258826-B1 HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS ELI LILLY AND COMPANY 2001-07-10 US disclosed
US-6087378-A THE ACTIVE BENZO(B)THIOPHENE COMPOUNDS FOR TREATING OSTEOPOROSIS AND CARDIOVASCULAR DISORDERS, ESPECIALLY HYPERLIPIDEMIA ELI LILLY AND COMPANY (US) 2000-07-11 US disclosed