SCHEMBL7943282

SCHEMBL7943282

NC1=NC(c2ccco2)Nc2cccc(Cl)c21

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 10/20 0.64
NOS3 P29474 7/20 0.55
NOS1 P29475 4/20 0.55
ALDH1A1 P00352 2/20 0.39
HPGD P15428 2/20 0.39
HSD17B10 Q99714 2/20 0.39
ALOX15 P16050 2/20 0.39
MAPK1 P28482 2/20 0.39
MEN1 O00255 1/20 0.39
USP2 O75604 1/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
THRB P10828 1/20 0.39
ALOX12 P18054 1/20 0.39
NR4A1 P22736 1/20 0.39
BRCA1 P38398 1/20 0.39
BLM P54132 1/20 0.39
KMT2A Q03164 1/20 0.39
KDM4E B2RXH2 2/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8379895 0.99 NOS2 (0.63) NOS2NOS3NOS1ALDH1A1HPGD
SCHEMBL7931766 0.84 NOS2 (0.70) NOS2NOS3NOS1ALDH1A1HPGD
Hydrochloric Acid SCHEMBL8517529 0.83 NOS2 (0.68) NOS2NOS3NOS1ALDH1A1HPGD
Hydrochloric Acid SCHEMBL8378401 0.80 NOS2 (0.59) NOS2NOS3NOS1ALDH1A1HPGD
SCHEMBL7931742 0.79 NOS2 (1.00) NOS2NOS3NOS1ALDH1A1HPGD
Hydrochloric Acid SCHEMBL8378184 0.77 NOS2 (0.97) NOS2NOS3NOS1ALDH1A1HPGD
SCHEMBL7803363 0.73 NOS2 (0.72) NOS2NOS3NOS1ALDH1A1HPGD
Hydrochloric Acid SCHEMBL8378587 0.72 NOS2 (0.70) NOS2NOS3NOS1ALDH1A1HPGD
SCHEMBL8056719 0.70 NOS3 (0.63) NOS2NOS3NOS1ALDH1A1MAPT
Hydrochloric Acid SCHEMBL8090620 0.69 NOS3 (0.61) NOS2NOS3NOS1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248745-B1 MIXTURE COMPRISING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR AND A 1,2-DIHYDRO-4-AMINOQUINAZOLINE DERIVATIVE INHIBITOR OF INDUCED NITRIC OXIDE SYNTHASE (INOS); NON-STEROIDAL ANTIINFLAMMATORY AGENTS ASTRAZENECA AB (SE) 2001-06-19 US claimed
CN-1204327-A Pharmaceutically active quinazoline compounds ASTRA PHARMA PROD (GB) 1999-01-06 CN disclosed