SCHEMBL7943320

SCHEMBL7943320

COc1ccc2c(c1[Zr](C)(C)(C1=CC(C)=CC1)=C(c1ccccc1)c1ccccc1)Cc1ccccc1-2

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.38
RAB9A P51151 2/20 0.38
MEN1 O00255 1/20 0.38
NPC1 O15118 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
LMNA P02545 1/20 0.31
SRD5A2 P31213 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8823143 0.85 KDM4E (0.41) KDM4ERAB9AMEN1NPC1ALDH1A1
SCHEMBL7941167 0.84 SRD5A2 (0.30) SRD5A2
SCHEMBL8154218 0.84 RAB9A (0.39) KDM4ERAB9AMEN1NPC1ALDH1A1
SCHEMBL8823165 0.83 MAPT (0.35) KDM4ERAB9AMEN1NPC1ALDH1A1
SCHEMBL7106984 0.81 NPC1 (0.34) RAB9ANPC1SRD5A2
SCHEMBL7106086 0.79
SCHEMBL7107716 0.75
SCHEMBL7942041 0.71
Hydrochloric Acid SCHEMBL8823191 0.71 KDM4E (0.38) KDM4ERAB9AMEN1NPC1ALDH1A1
SCHEMBL7945465 0.71 KDM4E (0.38) KDM4ERAB9AMEN1NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316558-B1 POLYMERIZING OLEFIN USING CATALYST COMPRISING TRANSITION METAL COMPOUND, COMPOUND CAPABLE OF A REACTING WITH TRANSITION METAL COMPOUND TO FORM A CATIONIC TRANSITION METAL COMPOUND, ORGANOMETALLIC TO FORM POLYOLEFIN TOSOH CORPORATION (JP) 2001-11-13 US disclosed
EP-0786466-A1 Transition metal compound, olefin polymerization catalyst comprising the compound, and process for production of olefin polymer Tosoh Corporation (JP) 1997-07-30 EP disclosed