Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 3/20 | 0.33 |
| ▸ | GABRD | O14764 | 3/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17570766 | 0.78 | TDP1 (0.36) | CHRNB2CHRNA4TDP1ALDH1A1MAPT | |
| SCHEMBL13948553 | 0.78 | TDP1 (0.36) | CHRNB2CHRNA4TDP1ALDH1A1MAPT | |
| SCHEMBL22023442 | 0.76 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL7942847 | 0.75 | FAAH (0.37) | TDP1ALDH1A1MAPTDDB1CRBN | |
| SCHEMBL8232751 | 0.74 | TDP1 (0.33) | TDP1ALDH1A1MAPTGABRPGABRD | |
| SCHEMBL7946203 | 0.74 | PARP1 (0.37) | GAAMMP12 | |
| SCHEMBL7947024 | 0.73 | POLB (0.40) | TDP1ALDH1A1MAPTGAAADORA2B | |
| SCHEMBL7945506 | 0.72 | TDP1 (0.36) | TDP1ALDH1A1MAPTADAM17GAA | |
| SCHEMBL7842456 | 0.71 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL14467196 | 0.71 | DAO (0.48) | TDP1ALDH1A1MAPTADAM17DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054278-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |