Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | MAX | P61244 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800333 | 0.89 | MAP2K1 (0.35) | MAP2K1MAP2K2 | |
| SCHEMBL7787202 | 0.84 | MAP2K1 (0.51) | MAP2K1MAP2K2KMT2AMYCMAX | |
| SCHEMBL7787206 | 0.76 | MAP2K1 (0.41) | MAP2K1MAP2K2KMT2APIM1CAMK2B | |
| SCHEMBL7800490 | 0.74 | MAP2K1 (0.50) | MAP2K1MAP2K2KMT2A | |
| SCHEMBL7784767 | 0.74 | IDO1 (0.51) | KMT2AMYCMAXAKR1C2AKR1C1 | |
| SCHEMBL6036200 | 0.74 | KMT2A (0.48) | MAP2K1MAP2K2KMT2AMYCMAX | |
| SCHEMBL7800477 | 0.72 | MYC (0.46) | KMT2AMYCMAXAKR1C2 | |
| SCHEMBL7800494 | 0.72 | MAP2K1 (0.50) | MAP2K1MAP2K2KMT2APIM1CAMK2B | |
| SCHEMBL6035286 | 0.72 | MAP2K1 (0.64) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL6036443 | 0.72 | MAP2K1 (0.81) | MAP2K1MAP2K2KMT2APIM1CAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140291-A1 | COMBINATION CHEMOTHERAPY COMPRISING A MITOTIC INHIBITOR AND A MEK INHIBITOR | WARNER-LAMBERT COMPANY LLC (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037141-A9 | COMBINATION CHEMOTHERAPY | WARNER LAMBERT CO (US) | 2000-12-07 | — | — | WO | disclosed |
| WO-2000037141-A1 | COMBINATION CHEMOTHERAPY | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |