Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.41 |
| ▸ | CTSV | O60911 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | MAX | P61244 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787206 | 0.90 | MAP2K1 (0.41) | MAP2K1MAP2K2MEN1KMT2ALMNA | |
| SCHEMBL7943544 | 0.84 | MAP2K1 (0.43) | MAP2K1MAP2K2KMT2AAKR1C2AKR1C1 | |
| SCHEMBL6035819 | 0.81 | CTSV (0.60) | MAPTMEN1KMT2AAKR1C2AKR1C1 | |
| SCHEMBL6035670 | 0.80 | MAP2K1 (0.59) | MAP2K1MAP2K2MAPTMEN1KMT2A | |
| SCHEMBL5678051 | 0.79 | MAPT (0.60) | MAPTMEN1KMT2AAKR1C2AKR1C1 | |
| SCHEMBL4851710 | 0.78 | MAP2K1 (0.78) | MAP2K1MAP2K2MEN1KMT2AIDO1 | |
| SCHEMBL29425477 | 0.78 | MAP2K1 (0.78) | MAP2K1MAP2K2MEN1KMT2AIDO1 | |
| SCHEMBL7784767 | 0.74 | IDO1 (0.51) | MAPTMEN1KMT2AAKR1C2AKR1C1 | |
| SCHEMBL6035244 | 0.74 | CTSV (0.60) | MAP2K1MAP2K2MAPTMEN1KMT2A | |
| SCHEMBL6036299 | 0.73 | IDO1 (0.56) | MAPTMEN1KMT2AAKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140067-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |