Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 9/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787202 | 0.90 | MAP2K1 (0.51) | MAP2K1MAP2K2MEN1KMT2ALMNA | |
| SCHEMBL7943544 | 0.76 | MAP2K1 (0.43) | MAP2K1MAP2K2KMT2APIM1CAMK2B | |
| SCHEMBL7784769 | 0.75 | NHERF1 (0.43) | MEN1KMT2ALMNATDP1MAPK1 | |
| SCHEMBL6138222 | 0.72 | MAP2K1 (0.60) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6035819 | 0.71 | CTSV (0.60) | MEN1KMT2ALMNAHDAC6MAPK1 | |
| SCHEMBL7854339 | 0.71 | MEN1 (0.46) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6035670 | 0.70 | MAP2K1 (0.59) | MAP2K1MAP2K2MEN1KMT2AMAPK1 | |
| SCHEMBL4861481 | 0.70 | MAP2K1 (0.56) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL5389889 | 0.69 | MAP2K1 (0.61) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL5678051 | 0.69 | MAPT (0.60) | MEN1KMT2ALMNATDP1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140067-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |