Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.63 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.57 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.57 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | RHOC | P08134 | 1/20 | 0.50 |
| ▸ | RHOA | P61586 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8370287 | 0.87 | SMN1; SMN2 (0.64) | KCNJ5KCNJ3ANO1KMT2AMEN1 | |
| SCHEMBL20921388 | 0.85 | TMPRSS4 (0.52) | PPARAANO1KMT2ACSNK1DMEN1 | |
| SCHEMBL6503306 | 0.84 | PPARA (0.61) | PPARAKCNJ5KCNJ3ANO1KMT2A | |
| SCHEMBL6496067 | 0.83 | KCNJ5 (0.66) | PPARAKCNJ5KCNJ3ANO1KMT2A | |
| SCHEMBL22775844 | 0.80 | ANO1 (0.57) | ANO1KMT2AMEN1LMNAGAA | |
| SCHEMBL29431308 | 0.80 | ANO1 (0.57) | ANO1KMT2AMEN1LMNAGAA | |
| SCHEMBL21198750 | 0.79 | GAA (0.56) | ANO1KMT2AMEN1LMNAGAA | |
| SCHEMBL31306676 | 0.79 | GAA (0.56) | ANO1KMT2AMEN1LMNAGAA | |
| SCHEMBL5757242 | 0.79 | ALDH1A1 (0.72) | PPARAKMT2AMEN1LMNAGAA | |
| SCHEMBL5756055 | 0.79 | PPARA (0.66) | PPARAKMT2AMEN1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | disclosed |
| US-5869509-A | TREAT DISORDERS RESPONSIVE TO OPENERS OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-02-09 | — | — | US | disclosed |