Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | RYR2 | Q92736 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31069587 | 0.82 | PDE3B (0.53) | METAP1PDE3BPDE3AACHECYP19A1 | |
| SCHEMBL2849831 | 0.82 | PDE3B (0.53) | METAP1PDE3BPDE3AACHECYP19A1 | |
| SCHEMBL8232389 | 0.76 | ALDH1A1 (0.45) | METAP1PDE3BPDE3AACHECYP19A1 | |
| SCHEMBL13090790 | 0.76 | PARP10 (0.49) | METAP1ACHECYP19A1CYP11B2HTR2A | |
| SCHEMBL8227734 | 0.72 | METAP1 (0.49) | METAP1ACHECYP19A1CYP11B2ALDH1A1 | |
| SCHEMBL10113037 | 0.71 | CLK4 (0.47) | METAP1PDE3BPDE3AACHEALDH1A1 | |
| SCHEMBL15467555 | 0.70 | METAP1 (0.49) | METAP1PDE3BPDE3AACHECA1 | |
| SCHEMBL4895916 | 0.70 | METAP1 (0.61) | METAP1PDE3BPDE3AACHECYP19A1 | |
| SCHEMBL6542702 | 0.69 | NPY5R (0.43) | PDE3BPDE3AACHECA1CA2 | |
| SCHEMBL246378 | 0.69 | PARP10 (0.63) | METAP1ACHECYP19A1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054278-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |
| WO-2007084455-A1 | HYDANTOIN COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007084451-A1 | HYDANTOIN DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007084415-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |