SCHEMBL7944047

SCHEMBL7944047

CCCCCNC1=NS(=O)(=O)c2cc(I)ccc2N1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
LMNA P02545 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
THRB P10828 1/20 0.37
TSHR P16473 1/20 0.37
ABCC8 Q09428 1/20 0.37
KCNJ11 Q14654 1/20 0.37
GPR84 Q9NQS5 10/20 0.33
HCAR3 P49019 1/20 0.33
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
GAA P10253 1/20 0.31
MGLL Q99685 1/20 0.31
ELANE P08246 2/20 0.30
ADRA2A P08913 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7953006 0.96 ALDH1A1 (0.38) ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4
SCHEMBL7957425 0.85 ALDH1A1 (0.53) ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4
Water SCHEMBL7944376 0.81 TAAR1 (0.41) ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4
SCHEMBL6555307 0.80 GPR84 (0.37) ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4
SCHEMBL7944207 0.79 ALDH1A1 (0.42) ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4
SCHEMBL6619663 0.79 LATS1 (0.40) LMNASMN1; SMN2GPR84HCAR3ELANE
SCHEMBL7944026 0.79 ALDH1A1 (0.42) ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4
SCHEMBL6618893 0.79 LATS1 (0.40) LMNASMN1; SMN2GPR84HCAR3ELANE
SCHEMBL7944400 0.78 KDM4E (0.45) ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4
SCHEMBL7944017 0.77 CA12 (0.40) ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3099304-A1 NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA Mayo Foundation for Medical Education and Research (US) 2016-12-07 EP disclosed
WO-2015117024-A1 NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2015-08-06 WO disclosed
US-6242443-B1 1,2,4-benzothiadiazine derivatives, their preparation and use NOVO NORDISK AIS (DK) 2001-06-05 US disclosed