Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7954667 | 0.97 | CA5A (0.32) | CA5A | |
| Hydrochloric Acid SCHEMBL7944196 | 0.70 | AKR1C3 (0.35) | CA5A | |
| Hydrochloric Acid SCHEMBL8590325 | 0.68 | KDM4E (0.32) | CA5A | |
| Iodide SCHEMBL7954665 | 0.67 | AKR1C3 (0.35) | CA5A | |
| Iodide SCHEMBL8591609 | 0.65 | KDM4E (0.32) | CA5A | |
| Hydrochloric Acid SCHEMBL3497424 | 0.63 | DNMT1 (0.35) | — | |
| SCHEMBL669554 | 0.63 | CA5A (0.67) | CA5A | |
| SCHEMBL12311026 | 0.62 | CA5A (0.48) | CA5A | |
| SCHEMBL1976289 | 0.61 | CA5A (0.52) | CA5A | |
| SCHEMBL7229486 | 0.60 | TP53 (0.41) | CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297253-B1 | INACTIVATING A NUCLEAR LOCALIZATION SIGNAL OF A PROTEIN COMPRISING CONTACTING THE PROTEIN WITH AN ARYL CARBONYL COMPOUND THAT FORMS STABLE REVERSIBLE COVALENT INTERACTIONS WITH NEIGHBORING BASIC AMINO ACID RESIDUES | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH | 2001-10-02 | — | — | US | claimed |