Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 4/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.46 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3510509 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7945667 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7942307 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7934749 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7945681 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7943566 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7942313 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7942323 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7943643 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7934822 | 0.98 | DNM1 (0.54) | DNM1SLC22A1SLC22A2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251379-B1 | KERATOSE WITH QUATERNARY AMMONIUM SALT AND SILICONE DERIVATIVES | SHISEIDO CO., LTD. (JP) | 2001-06-26 | — | — | US | disclosed |