Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 19/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 8/20 | 0.49 |
| ▸ | PLA2G10 | O15496 | 5/20 | 0.49 |
| ▸ | PLA2G5 | P39877 | 4/20 | 0.49 |
| ▸ | PLA2G2E | Q9NZK7 | 4/20 | 0.49 |
| ▸ | PLA2G2F | Q9BZM2 | 2/20 | 0.46 |
| ▸ | PLA2G2D | Q9UNK4 | 2/20 | 0.46 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.46 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.46 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.46 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.46 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30410934 | 1.00 | PLA2G2A (0.49) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL819564 | 0.91 | PLA2G2A (0.55) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL6776872 | 0.88 | PLA2G2A (0.55) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL817486 | 0.85 | PLA2G2A (0.57) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL29029768 | 0.85 | PTGS2 (0.40) | PLA2G2A | |
| SCHEMBL6692598 | 0.84 | PLA2G2A (0.48) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL6688806 | 0.84 | PLA2G2A (0.56) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL6688799 | 0.84 | PLA2G2A (0.56) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL8063373 | 0.84 | PLA2G2A (0.51) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL6781718 | 0.83 | PLA2G2A (0.53) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116585306-A | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-109562098-B | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-107249578-B | Method for treating envenomation and related pharmaceutical composition, system and kit | 奥菲瑞克斯股份有限公司 | 2021-01-26 | — | — | CN | disclosed |
| WO-2001066111-A1 | COMPOSITIONS CONTAINING POTENTIAL SPLA2 INHIBITORS FOR THE TREATMENT OF PAIN | ELI LILLY AND COMPANY (US) | 2001-09-13 | — | — | WO | disclosed |