Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.78 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14030783 | 1.00 | ADORA2A (0.78) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL15459910 | 0.89 | ADORA2A (0.65) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL28884590 | 0.89 | ADORA2A (0.78) | ADORA2AADORA2BADORA3ADORA1 | |
| Nelarabine SCHEMBL1818971 | 0.88 | CYP2C19 (0.71) | ADORA2AADORA2BADORA3ADORA1 | |
| Nelarabine SCHEMBL14031852 | 0.88 | CYP2C19 (0.71) | ADORA2AADORA2BADORA3ADORA1 | |
| Bvt.115959 SCHEMBL24838605 | 0.88 | ADORA2A (1.00) | ADORA2AADORA2BADORA3ADORA1 | |
| Bvt.115959 SCHEMBL13224547 | 0.88 | ADORA2A (1.00) | ADORA2AADORA2BADORA3ADORA1 | |
| Nelarabine SCHEMBL20769831 | 0.88 | CYP2C19 (0.71) | ADORA2AADORA2BADORA3ADORA1 | |
| Nelarabine SCHEMBL2143756 | 0.88 | CYP2C19 (0.71) | ADORA2AADORA2BADORA3ADORA1 | |
| Nelarabine SCHEMBL13657986 | 0.88 | CYP2C19 (0.71) | ADORA2AADORA2BADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211158-B1 | Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents | ROCHE DIAGNOSTICS GMBH (DE) | 2001-04-03 | — | — | US | disclosed |