Nelarabine

Nelarabine

SCHEMBL1818971

COc1nc(N)nc2c1ncn2C1O[C@H](CO)[C@@H](O)[C@@H]1O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.71
ADORA2A P29274 3/20 0.70
ADORA3 P0DMS8 2/20 0.70
ADORA1 P30542 2/20 0.70
ADORA2B P29275 2/20 0.70
SLC29A1 Q99808 5/20 0.67
PGK1 P00558 1/20 0.64
PGK2 P07205 1/20 0.64
LMNA P02545 1/20 0.61
NT5E P21589 1/20 0.61
HIF1A Q16665 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nelarabine SCHEMBL31326718 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL9937290 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL14031852 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL18820 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL13575801 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL2143756 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL18321891 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL13657986 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL20769831 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL29077509 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724107-A2 OPHTHALMIC FILMS Fount Bio, Inc. (US) 2026-04-15 EP disclosed
WO-2024254278-A9 OPHTHALMIC FILMS FOUNT BIO, INC. (US) 2025-02-13 WO disclosed
WO-2024254278-A2 OPHTHALMIC FILMS FOUNT BIO, INC. (US) 2024-12-12 WO disclosed
CN-113710225-B Delivery and retention of active agents within the skin 范德生物公司 2024-06-21 CN disclosed
CN-108350030-B Skin permeable peptides and methods of use thereof 汉阳大学校产学协力团 2022-12-13 CN disclosed
US-20220175819-A1 DELIVERY AND RETENTION OF ACTIVE AGENTS WITHIN THE SKIN FOUNT BIO, INC. 2022-06-09 US disclosed
EP-3955887-A1 DELIVERY AND RETENTION OF ACTIVE AGENTS WITHIN THE SKIN Fount Bio, Inc. (US) 2022-02-23 EP disclosed
CN-113710225-A Delivery and retention of active agents within the skin 范德生物公司 2021-11-26 CN disclosed
EP-3336098-B1 SKIN PERMEABLE PEPTIDE AND METHOD FOR USING SAME IUCF HYU (KR) 2021-08-11 EP disclosed
US-10858395-B2 Skin-penetrating peptide and method for using same IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) (KR) 2020-12-08 US disclosed
US-8518871-B2 Skin permeating and cell entering (SPACE) peptides and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-08-27 US disclosed
CN-103201386-A Skin penetrating and cell entering (SPACE) peptides and methods of use thereof UNIV CALIFORNIA 2013-07-10 CN disclosed
US-20130011392-A1 METHOD FOR ASSESSING THE ABILITY OF A PATIENT TO RESPOND TO OR BE SAFELY TREATED BY A NUCLEOSIDE ANALOG BASED-CHEMOTHERAPY ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE (FR) 2013-01-10 US disclosed
WO-2012064429-A2 SKIN PERMEATING AND CELL ENTERING (SPACE) PEPTIDES AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-05-18 WO disclosed
WO-2011061278-A1 A METHOD FOR ASSESSING THE ABILITY OF A PATIENT TO RESPOND TO OR BE SAFELY TREATED BY A NUCLEOSIDE ANALOG BASED-CHEMOTHERAPY UNIVERSITE DE LA MEDITERRANEE (FR) 2011-05-26 WO disclosed
US-7427600-B2 Active agent delivery systems and methods for protecting and administering active agents SHIRE LLC (US) 2008-09-23 US disclosed
US-7427600-B2 Active agent delivery systems and methods for protecting and administering active agents SHIRE LLC (US) 2008-09-23 US disclosed
US-20070232529-A1 mesalamine covalently attached to carrier peptide at C-terminus, interspersed and/or side chain; releasing into bloodstream; reducing dosage NEW RIVER PHARMACEUTICALS INC. (US) 2007-10-04 US disclosed
US-20070232529-A1 mesalamine covalently attached to carrier peptide at C-terminus, interspersed and/or side chain; releasing into bloodstream; reducing dosage NEW RIVER PHARMACEUTICALS INC. (US) 2007-10-04 US disclosed
EP-0539479-A1 HETEROCYCLIC COMPOUNDS. WELLCOME FOUND (GB) 1993-05-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220175819-A1 DELIVERY AND RETENTION OF ACTIVE AGENTS WITHIN THE SKIN MMP8, MMP7, MMP1 CYP2C19 4669/4885ADORA2A 1212/4885ADORA3 1854/4885
US-20070232529-A1 mesalamine covalently attached to carrier peptide at C-terminus, interspersed and/or side chain; releasing into bloodstream; reducing dosage VIP, BST2, FCGR3B CYP2C19 889/4885ADORA2A 573/4885ADORA3 619/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.