Nelarabine

Nelarabine

SCHEMBL2143756

COc1nc(N)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.71
ADORA2A P29274 3/20 0.70
ADORA3 P0DMS8 2/20 0.70
ADORA1 P30542 2/20 0.70
ADORA2B P29275 2/20 0.70
SLC29A1 Q99808 5/20 0.67
PGK1 P00558 1/20 0.64
PGK2 P07205 1/20 0.64
LMNA P02545 1/20 0.61
NT5E P21589 1/20 0.61
HIF1A Q16665 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nelarabine SCHEMBL31326718 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL1818971 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL9937290 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL14031852 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL18820 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL13575801 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL18321891 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL13657986 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL20769831 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B
Nelarabine SCHEMBL29077509 1.00 CYP2C19 (0.71) CYP2C19ADORA2AADORA3ADORA1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 692 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250340868-A1 POLYNUCLEOTIDES ENCODING LINKED ANTIGENS AND USES THEREOF STEMCELL TECHNOLOGIES CANADA INC (CA) 2025-11-06 US claimed
EP-4634380-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-10-22 EP claimed
US-12357664-B2 Optimized oncolytic viruses and uses thereof SATOR THERAPEUTICS (US) 2025-07-15 US claimed
WO-2025137275-A1 NOVEL CAS NUCLEASES AND POLYNUCLEOTIDES ENCODING THE SAME MODERNATX, INC. (US) 2025-06-26 WO claimed
EP-4565692-A2 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-06-11 EP claimed
EP-4561602-A1 POLYNUCLEOTIDES ENCODING LINKED ANTIGENS AND USES THEREOF Stemcell Technologies Canada Inc. (CA) 2025-06-04 EP claimed
CN-119866224-A Polynucleotide encoding a linking antigen and uses thereof 加拿大干细胞技术公司 2025-04-22 CN claimed
EP-4514328-A1 LIPID NANOPARTICLES COMPRISING VENEZUELAN EQUINE ENCEPHALITIS (VEE) REPLICON AND USES THEREOF Strand Therapeutics Inc. (US) 2025-03-05 EP claimed
US-20250049950-A1 NUCLEIC ACIDS AND METHODS OF TREATMENT FOR CYSTIC FIBROSIS ARCTURUS THERAPEUTICS, INC. 2025-02-13 US claimed
WO-2025024123-A1 NOVEL CITICOLINE DERIVATIVES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-01-30 WO claimed
US-20190284260-A1 RNA-CODED ANTIBODY CUREVAC AG (DE) 2019-09-19 US claimed
EP-3518947-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2019-08-07 EP claimed
WO-2018064134-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2018-04-05 WO claimed
US-20180085411-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF SATOR THERAPEUTICS 2018-03-29 US claimed
CN-102250178-A Synthesis of nelarabine JIANGSU CHIA TAI TIANQING PHAR 2011-11-23 CN claimed
CN-101348511-A Synthesis and refinement of nelarabine JIANGSU CHIA TAI TIANQING PHAR (CN) 2009-01-21 CN claimed
US-20050187180-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2005-08-25 US claimed
EP-0661291-B1 Solid phase synthesis of oligoribonucleotide AVENTIS PHARMA GMBH (DE) 2001-03-07 EP claimed
US-5652358-A Solid-phase synthesis of oligoribonucleotides HOECHST AKTIENGESELLSCHAFT (DE) 1997-07-29 US claimed
EP-0661291-A1 Solid phase synthesis of oligoribonucleotide HOECHST AKTIENGESELLSCHAFT (DE) 1995-07-05 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250049950-A1 NUCLEIC ACIDS AND METHODS OF TREATMENT FOR CYSTIC FIBROSIS CFTR, RNMT, RNGTT CYP2C19 4610/4885ADORA2A 1288/4885ADORA3 687/4885
US-20050187180-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA SAMHD1, BCDIN3D, DCTD CYP2C19 3339/4885ADORA2A 2027/4885ADORA3 1762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.