Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30468969 | 0.73 | POLB (0.40) | POLBHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2458873 | 0.68 | POLB (0.39) | POLBHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL367099 | 0.64 | POLB (0.56) | POLBHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13752162 | 0.63 | RAB9A (0.70) | POLBHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9442103 | 0.63 | POLB (0.50) | POLBHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7048870 | 0.63 | — | — | |
| SCHEMBL332623 | 0.62 | MAOA (0.63) | POLBHSD17B10NPC1RAB9ASMN1; SMN2 | |
| Cyclohexane SCHEMBL28084543 | 0.62 | MAOA (0.57) | POLBHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15559910 | 0.62 | POLB (0.40) | POLBHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28084553 | 0.61 | MAOA (0.61) | POLBHSD17B10NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288123-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | CAMBRIDGE NEUROSCIENCES, INC. | 2001-09-11 | — | — | US | disclosed |