Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8128722 | 0.99 | MAPT (0.45) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7953997 | 0.93 | ALDH1A1 (0.43) | MAPTALOX15ROCK2CYP3A4LMNA | |
| SCHEMBL7951748 | 0.91 | ROCK2 (0.49) | MAPTALOX15ROCK2CYP3A4LMNA | |
| Hydrochloric Acid SCHEMBL8135520 | 0.90 | ROCK2 (0.49) | MAPTALOX15ROCK2CYP3A4LMNA | |
| SCHEMBL6299445 | 0.88 | ROCK2 (0.56) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7951842 | 0.87 | MEN1 (0.53) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7951760 | 0.87 | MAPT (0.61) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8134734 | 0.86 | MEN1 (0.53) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7953963 | 0.84 | KMT2A (0.56) | MAPTALOX15SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL6806470 | 0.83 | MAPT (0.44) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | claimed |
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |
| EP-0986559-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054184-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-03 | — | — | WO | disclosed |