Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 17/20 | 0.77 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.77 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17776365 | 1.00 | OPRK1 (0.77) | OPRK1OPRM1OPRD1CYP2D6CYP3A4 | |
| SCHEMBL17776358 | 1.00 | OPRK1 (0.77) | OPRK1OPRM1OPRD1CYP2D6CYP3A4 | |
| SCHEMBL17776366 | 0.94 | OPRK1 (0.76) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL17776369 | 0.94 | OPRK1 (0.79) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9450279 | 0.94 | OPRK1 (0.79) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL17776372 | 0.94 | OPRK1 (0.79) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9450203 | 0.94 | OPRK1 (0.75) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9449902 | 0.93 | OPRK1 (0.74) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9449814 | 0.93 | OPRK1 (0.73) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9450328 | 0.93 | OPRK1 (0.74) | OPRK1OPRM1OPRD1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998049141-A1 | KAPPA OPIOID AGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-11-05 | — | — | WO | claimed |
| WO-2001015678-A2 | TOPICAL USE OF KAPPA OPIOID AGONISTS TO TREAT OTIC PAIN | ALCON LABORATORIES, INC. (US) | 2001-03-08 | — | — | WO | disclosed |
| US-6133307-A | 2-BENZOFURAN-4-YL-N-(2-(3-HYDROXY-PYRROLIDIN-1-YL)-1-PHENYL-ETHYL) -N-METHYL-ACETAMIDE, FOR EXAMPLE; TREATMENT OF ARTHRITIS, HYPERTENSION, PAIN, INFLAMMATION, MIGRAINE, INFLAMMATORY GASTROINTESTINAL DISORDERS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| US-5232978-A | 1-(2-arylethyl)-pyrrolidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0483580-A2 | 1-(2-Arylethyl)-pyrrolidine | MERCK PATENT GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |