Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 18/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.73 |
| ▸ | OPRD1 | P41143 | 13/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658794 | 1.00 | OPRK1 (0.74) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9449798 | 1.00 | OPRK1 (0.74) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9450328 | 1.00 | OPRK1 (0.74) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9658787 | 1.00 | OPRK1 (0.74) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9450224 | 1.00 | OPRK1 (0.74) | OPRK1OPRM1OPRD1CYP2D6 | |
| Hydrochloric Acid SCHEMBL9449915 | 0.98 | OPRK1 (0.71) | OPRK1OPRM1OPRD1CYP2D6 | |
| Hydrochloric Acid SCHEMBL9449912 | 0.98 | OPRK1 (0.71) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL7945544 | 0.93 | OPRK1 (0.77) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL17776358 | 0.93 | OPRK1 (0.77) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL17776365 | 0.93 | OPRK1 (0.77) | OPRK1OPRM1OPRD1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232978-A | 1-(2-arylethyl)-pyrrolidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0483580-A2 | 1-(2-Arylethyl)-pyrrolidine | MERCK PATENT GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |