Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361562 | 0.79 | MAP4K4 (0.44) | — | |
| SCHEMBL7954135 | 0.75 | GAA (0.43) | S1PR4MEN1KMT2A | |
| SCHEMBL2900836 | 0.75 | HTT (0.37) | — | |
| SCHEMBL2897755 | 0.75 | SMN1; SMN2 (0.55) | MEN1KMT2A | |
| SCHEMBL7955819 | 0.73 | SLC6A4 (0.45) | MEN1KMT2A | |
| SCHEMBL10393866 | 0.73 | KDM4E (0.36) | MEN1KMT2A | |
| SCHEMBL2897754 | 0.71 | MAP4K4 (0.43) | TGFBR1KMT2A | |
| SCHEMBL693585 | 0.71 | KMT2A (0.49) | MEN1KMT2A | |
| SCHEMBL2894972 | 0.70 | MEN1 (0.52) | MEN1KMT2A | |
| SCHEMBL2901162 | 0.70 | SLC6A2 (0.32) | S1PR4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235758-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-22 | — | — | US | disclosed |
| EP-0808312-B1 | INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-5990133-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY OR DEPRESSION | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |